—>> A strong antibody response is dangerous ! <<— (work in progress!)
—>> no secret ! <<— Isn’t it interesting that high-titre NAbs observed in deceased patients weren’t a guarantee of protection
It is considered critical that SARS-CoV-2 vaccines provoke a strong immune response
https://journals.asm.org/doi/10.1128/Spectrum.00341-21
High antibody response to two-dose SARS-CoV-2 messenger RNA vaccination in patients with rheumatic and musculoskeletal diseases
https://ard.bmj.com/content/80/10/1351
The BNT162b2 mRNA vaccine remarkably enhanced antibody responses after the second dose in infection-naïve individuals and after the first dose in previously infected HCWs of all ages and genders.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.722766/full
van der Voort and colleagues reported that a group of NAb positive MS patients deteriorated more rapidly than expected over the following years, suggesting that the presence of IFNβ NAbs may in itself be a risk factor for MS progression by an unknown mechanism
the patients with persistent NAbs in their study did have indications of a more active disease prior to treatment start, although this was not significant in a small cohort of 71 patients. To our knowledge, no further studies have attempted to follow up on this observation in spite of its importance given that thousands of MS patients are rendered IFNβ NAb positive every year even today.
High titer NAbs to IFNβ are associated with higher disease activity, persisting even after IFNβ discontinuation or switch. These results support use of highly efficient treatment earlier in patients with active disease, to avoid these complications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593513/
In patients with moderate to severe COVID-19 pneumonia, high-titer anti–SARS-CoV-2 CP did not reduce the progression to severe respiratory failure or death within 30 days.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786680
The combined analysis showed a decreased survival related to high titre measles vaccine compared with standard titre vaccines, though solely among females. As a result of these studies from West Africa and a study from Haiti, WHO has recommended that high titre measles vaccine no longer be used.
https://pubmed.ncbi.nlm.nih.gov/8671571/
decreased survival related to high titre vaccine compared with standard titre vaccines
The trials were not designed to study long term mortality.
WHO has recommended that high titre vaccine no longer be used.
https://academic.oup.com/ije/article/25/3/665/757122
ICU patients had an accelerated and augmented NAb response compared to non-ICU patients
as demonstrated in influenza vaccine trials, antibodies can also worsen disease cases, especially for dengue virus infection.
Multivariate analysis showed that oxygen requirement and fever during admission were the only clinical factors independently associated with higher NAb titers.
whether or not neutralizing antibodies themselves can mediate disease severity remains to be investigated.
https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1791738
Since high-titre vaccines have been associated with higher mortality than SW-std, further improvements in measles control before 9 months may require two-dose strategies with standard vaccines.
https://academic.oup.com/trstmh/article-abstract/87/6/697/1932933?redirectedFrom=fulltext
UPDATED:
Published: 17 May 2023
“IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein”
"However, if people who are the most affected by COVID-19 (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them?"
https://www.mdpi.com/2076-393X/11/5/991
UPDATED
Antibody response has been used to justify vaccine efficacy. However, it is not possible to establish a baseline with antibodies. There were cases were people died with high amounts of antibodies and low. Same for people who survived Covid.
Wow.
Vaccines are beneficial only for Pharma (and Bill gates') bank accounts.
Published: 17 May 2023
“IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein”
"However, if people who are the most affected by COVID-19 (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them?"
https://www.mdpi.com/2076-393X/11/5/991